形式
chloroform solution
包装
pkg of 1 × 4 mL (141101C-100mg)
pkg of 5 × 4 mL (141101C-500mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
浓度
25 mg/mL (141101C-100mg)
25 mg/mL (141101C-500mg)
脂质类型
lipid extracts
运输
dry ice
储存温度
−20°C
一般描述
Brain Extract Polar comprises phosphatidylethanolamine as major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.
应用
Brain Extract Polar has been used as an artificial membrane solution component for permeability studies. It may be used for coating donor plate during parallel artificial membrane permeability assay (PAMPA) to study blood-brain barrier penetration. It may be used in liposome preparation for dynamin self-assembly assay.
生化/生理作用
Brain lipid, especially the polar fraction plays a key role in the inhibition of prion seeded amyloid formation. Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes.
包装
5 mL Clear Glass Sealed Ampule (141101C-100mg)
5 mL Clear Glass Sealed Ampule (141101C-500mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system, Liver,Kidney
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
易制毒化学品（2类）
危险化学品
Prediction of blood-brain barrier permeation of alpha-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis
Vucicevic J, et al.
European Journal of Pharmaceutical Sciences, 68(10), 94-105 (2015)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Chierrito TPC, et al.
European Journal of Medicinal Chemistry, 145(10), 431-444 (2018)
Irene Paterniti et al.
PloS one, 6(1), e15937-e15937 (2011-02-08)
Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
Kalirin12 interacts with dynamin
Xin X, et al.
BMC Neuroscience, 10(1), 61-61 (2009)
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