等级
cGMP
质量水平
同位素纯度
≥99 atom % 13C
检测方案
≥95% (CP)
bp
165 °C
mp
11-12 °C
质量偏移
M+1
运输
dry ice
储存温度
-10 to -25°C
SMILES字符串
CC(=O)[13C](O)=O
InChI
1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1
InChI key
LCTONWCANYUPML-LBPDFUHNSA-N
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一般描述
Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.
应用
Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.
包装
Typically, this product is available to ship immediately from stock. Contact Stable Isotopes Customer Service to discuss quantity and packaging needs.
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Corr. 1C
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.
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