W239607
丁二酸二甲酯
98%, FG
别名:
丁二酸二甲酯, 琥珀酸二甲酯
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关于此项目
线性分子式:
CH3OCOCH2CH2COOCH3
化学文摘社编号:
分子量:
146.14
FEMA Number:
2396
Council of Europe no.:
439
UNSPSC Code:
12164502
PubChem Substance ID:
Flavis number:
9.445
EC Number:
203-419-9
NACRES:
NA.21
MDL number:
Beilstein/REAXYS Number:
956776
Organoleptic:
green; fruity; floral; sweet
Grade:
FG, Halal, Kosher
Biological source:
synthetic
Food allergen:
no known allergens
SMILES string
COC(=O)CCC(=O)OC
InChI
1S/C6H10O4/c1-9-5(7)3-4-6(8)10-2/h3-4H2,1-2H3
InChI key
MUXOBHXGJLMRAB-UHFFFAOYSA-N
biological source
synthetic
grade
FG, Halal, Kosher
reg. compliance
EU Regulation 1334/2008 & 178/2002, FDA 21 CFR 117, FDA 21 CFR 172.515
vapor pressure
0.3 mmHg ( 20 °C)
assay
98%
autoignition temp.
689 °F
expl. lim.
8.5 %
refractive index
n20/D 1.419 (lit.)
bp
200 °C (lit.)
mp
16-19 °C (lit.)
density
1.117 g/mL at 25 °C (lit.)
application(s)
flavors and fragrances
documentation
see Safety & Documentation for available documents
food allergen
no known allergens
organoleptic
green; fruity; floral; sweet
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General description
丁二酸二甲酯可作为调味剂用于食品工业。
Application
- 代谢旁路挽救了阿尔茨海默病患者神经元中异常S-亚硝基化诱导的TCA循环抑制和突触损失。: 这项研究讨论了琥珀酸二甲酯之类的代谢中间体在规避阿尔茨海默病生化阻滞中的作用，提供了潜在的治疗途径（Andreyev et al., 2024）。
- RIFM香精成分安全性评估更新，丁二酸二甲酯，CAS等级号码106-65-0。: 作为香精成分的丁二酸二甲酯的全面安全评估，强调了其毒理学特征和安全使用参数（Api et al., 2023）。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
201.2 °F - closed cup
flash_point_c
94 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Burdock, GA
Encyclopedia of Food and Color Additives, 1, 878-879 (1997)
Lili Yang et al.
The Journal of biological chemistry, 283(32), 21978-21987 (2008-06-12)
We conducted a study coupling metabolomics and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. Rat livers were perfused with lactate or pyruvate +/- aminooxyacetate or mercaptopicolinate in the presence of 40% enriched NaH(13)CO(3). Other livers were perfused
André Mukala-Nsengu et al.
Biochemical pharmacology, 67(5), 981-988 (2004-04-24)
The relative contribution of glycolysis vs. oxidative metabolism to the stimulus secretion coupling mechanism of beta-cells was investigated in isolated islets. For that purpose, the secretory and intracellular calcium responses of islets to both glucose and succinic acid dimethyl ester
J Cancelas et al.
International journal of molecular medicine, 8(3), 269-271 (2001-08-09)
It was recently proposed that suitable succinic acid esters could be used to potentiate the insulinotropic action of glucagon-like peptide 1 (GLP-1) in the treatment of type-2 diabetes mellitus. In such a perspective, the present study aimed mainly at investigating
J A Garcia-Martinez et al.
International journal of molecular medicine, 6(3), 319-321 (2000-08-10)
Adult rats, that had been injected with streptozotocin during the neonatal period, received a primed constant infusion of succinic acid dimethyl ester (SAD; 0.5 micromol followed by 0.25 micromol x min(-1), both per g body wt.) in saline for 15
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