W238104
氢化肉桂酸内酯
≥99%, FCC, FG
别名:
1,2-苯并二氢吡喃酮, 二氢香豆素, 苯并二氢吡喃酮
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关于此项目
经验公式（希尔记法）:
C9H8O2
化学文摘社编号:
分子量:
148.16
FEMA Number:
2381
Council of Europe no.:
535
UNSPSC Code:
12164502
PubChem Substance ID:
Flavis number:
13.009
EC Number:
204-354-9
NACRES:
NA.21
MDL number:
Organoleptic:
coconut; coumarin; sweet
Grade:
FG, Halal, Kosher
Biological source:
synthetic
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens
SMILES string
O=C1CCc2ccccc2O1
InChI
1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2
InChI key
VMUXSMXIQBNMGZ-UHFFFAOYSA-N
biological source
synthetic
grade
FG, Halal, Kosher
agency
meets purity specifications of JECFA
reg. compliance
EU Regulation 1334/2008 & 178/2002, FCC, FDA 21 CFR 117
assay
≥99%
refractive index
n20/D 1.556 (lit.)
bp
272 °C (lit.)
mp
24-25 °C (lit.)
density
1.169 g/mL at 25 °C (lit.)
application(s)
flavors and fragrances
documentation
see Safety & Documentation for available documents
food allergen
no known allergens
organoleptic
coconut; coumarin; sweet
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General description
二氢香豆素通常在食品和化妆品工业中用作调味成分。它天然存在于草木犀（甜三叶草）中。
Application
- 新型辐射分解诱导的二氢香豆素作为有效的酪氨酸酶抑制剂：本研究鉴定了通过辐射分解产生的新型二氢香豆素，证明了其作为有效酪氨酸酶抑制剂的潜力，这在皮肤病学及相关领域具有重要应用前景。（Jeong 等人，2024 年）（Jeong 等人，2024 年）。
Biochem/physiol Actions
10ppm 时的味道
Other Notes
天然存在：草木樨和鹿舌。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
>212.0 °F - closed cup
flash_point_c
> 100 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Marc Vocanson et al.
Contact dermatitis, 57(6), 361-364 (2007-11-09)
There is controversy as to whether coumarin, an ingredient in cosmetics and fragrances, is a contact allergen involved in fragrance allergy. We recently showed that the purity of coumarin is a critical parameter for its allergenicity because coumarin preparations containing
Shiyong Peng et al.
Organic & biomolecular chemistry, 10(13), 2537-2541 (2012-03-01)
3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under
J P Guillot et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 21(6), 795-805 (1983-12-01)
An evaluation was made of the different protocols recommended by the Association Française de Normalisation (AFNOR) for assessing the sensitizing potential of chemicals in the guinea-pig. The methods studied were those of Magnusson & Kligman (J. invest. Derm. 1969, 52
Jie Chen et al.
The Journal of organic chemistry, 77(2), 999-1009 (2011-12-20)
A facile and enantioselective approach toward 3,4-dihydroisocoumarin was developed. The method involved an amino-thiocarbamate catalyzed enantioselective bromocyclization of styrene-type carboxylic acids, yielding 3-bromo-3,4-dihydroisocoumarins with good yields and ee's. 3-Bromo-3,4-dihydroisocoumarins are versatile building blocks for various dihydroisocoumarin derivatives in which the
Sharona Shachan-Tov et al.
Free radical biology & medicine, 49(10), 1516-1521 (2010-08-31)
Afri et al. reported in this journal (Free Radic. Biol. Med.32:605-618; 2002) that a direct relationship exists between the depth of alkanoylcoumarins 1 within the liposomal lipid bilayer and the rate at which they undergo superoxide-mediated saponification. These results were
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