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Merck
CN

QBD10850

Sigma-Aldrich

Thiol-dPEG®12-acid

>95% (HPLC)

别名:

CT(PEG)12, Carboxy-PEG-Thiol, Carboxy-PEG12-Thiol, HS-PEG12-COOH, Thiol-PEG12-acid

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About This Item

经验公式(希尔记法):
C27H54O14S
分子量:
634.77
MDL编号:
UNSPSC代码:
12162002
NACRES:
NA.22

检测方案

>95% (HPLC)

形式

solid or viscous liquid

反应适用性

reaction type: Pegylations

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

特点和优势

Thiol-dPEG12-acid is a single molecular weight, discrete-length polyethylene glycol (dPEG) crosslinking PEGylation reagent. One end of the crosslinker terminates in a sulfhydryl (thiol) group. Propionic acid terminates the opposite end. The thiol end of the molecule forms dative bonds with gold. Moreover, it forms thioether bonds with maleimide and bromoacetate groups and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface. The monodispersed dPEG spacer is 39 atoms (46.8 Å) long.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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