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方案
>95% (HPLC)
表单
solid or viscous liquid
反应适用性
reaction type: Pegylations
聚合物结构设计
shape: linear
functionality: heterobifunctional
运输
ambient
储存温度
−20°C
SMILES字符串
NCCOCCOCCOCCOCCC(=O)O
InChI
1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChI key
DKUZHSDZSMQOGQ-UHFFFAOYSA-N
特点和优势
Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 Å) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.
法律信息
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mark Lefever et al.
Bioconjugate chemistry, 21(10), 1773-1778 (2010-09-04)
A novel method of linking haptens to deoxycytidine 5'-triphosphate via microwave-mediated bisulfate-catalyzed transamination with hydrazine has been developed. This method enables the tethering of small molecule haptens to dCTP via a discrete polyethylene glycol (PEG) spacer, yielding N(4)-aminodeoxycytidine 5'-triphosphate-dPEG-haptens. This
Lijun Wang et al.
Molecular pharmaceutics, 6(1), 231-245 (2008-12-11)
This report describes the synthesis of two cyclic RGD (Arg-Gly-Asp) conjugates, HYNIC-2PEG(4)-dimer (HYNIC = 6-hydrazinonicotinyl; 2PEG(4)-dimer = E[PEG(4)-c(RGDfK)](2); and PEG(4) = 15-amino-4,7,10,13-tetraoxapentadecanoic acid) and HYNIC-3PEG(4)-dimer (3PEG(4)-dimer = PEG(4)-E[PEG(4)-c(RGDfK)](2)), and evaluation of their (99m)Tc complexes [(99m)Tc(HYNIC-2PEG(4)-dimer)(tricine)(TPPTS)] ((99m)Tc-2PEG(4)-dimer: TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate)
Kohei Sano et al.
Bioconjugate chemistry, 24(5), 811-816 (2013-04-23)
The ability to switch optical imaging probes from the quenched (off) to the active state (on) has greatly improved target to background ratios. The optimal activation efficiency of an optical probe depends on complete quenching before activation and complete dequenching
Jiyun Shi et al.
Bioconjugate chemistry, 20(4), 750-759 (2009-03-27)
Radiolabeled cyclic RGD (Arg-Gly-Asp) peptides represent a new class of radiotracers with potential for early tumor detection and noninvasive monitoring of tumor metastasis and therapeutic response in cancer patients. This article describes the synthesis of two cyclic RGD peptide dimer
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