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Merck
CN

QBD10194

NHS-S-S-dPEG®4-biotin (cleavable)

别名:

2,5-Dioxo-1-pyrrolidinyl 29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosanoate, Polyethylene glycol

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关于此项目

经验公式（希尔记法）:
C30H49N5O11S3
化学文摘社编号:
1260247-51-5
分子量:
751.93
UNSPSC Code:
51171641
PubChem Substance ID:
329823886
NACRES:
NA.22

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InChI

1S/C30H49N5O11S3/c36-24(4-2-1-3-23-29-22(21-47-23)33-30(41)34-29)31-9-12-43-14-16-45-18-17-44-15-13-42-11-7-25(37)32-10-20-49-48-19-8-28(40)46-35-26(38)5-6-27(35)39/h22-23,29H,1-21H2,(H,31,36)(H,32,37)(H2,33,34,41)

InChI key

QEVJWOMRMWJABZ-UHFFFAOYSA-N

SMILES string

O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O

assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations
reagent type: cross-linking reagent

functional group

disulfide

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

相关类别

Features and Benefits

NHS-S-S-dPEG®4-biotin is used extensively to label molecules that contain a free amine with biotin. This dPEG® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. NHS-S-S-dPEG®4-biotin contains a disulfide group in the linear chain, allowing the biotin to be cleaved reductively from the labeled molecule.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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