Acid-dPEG^®₂₅-NHS ester

Acid-dPEG₂₅-NHS ester is an amine-reactive crosslinker designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG) backbone. The correct use of this product eliminates intramolecular crosslinking. The dPEG backbone is amphiphilic. Consequently, it imparts water solubility to molecules to which it is conjugated. The dPEG spacer is 79 atoms (92.5 Å) long. The dPEG spacer in this product is the monodisperse PEG equivalent of PEG₁₀₀₀. One end of the chain terminates in a propionic acid group. The other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid. While both ends of the molecule can react with free amines such as the ε-amine group of lysine, only one end of the dPEG spacer is activated as the NHS ester. This construction permits only one end of the spacer to react at a time, thus giving the user greater control over crosslinking molecules using this product.

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign