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检测方案
>90%
形式
solid or viscous liquid
反应适用性
reactivity: amine reactive
reagent type: cross-linking reagent
reactivity: thiol reactive
官能团
NHS ester
聚合物结构设计
shape: linear
functionality: heterobifunctional
运输
ambient
储存温度
−20°C
SMILES字符串
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O
特点和优势
Phthalimidooxy-dPEG®4-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.
法律信息
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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