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Kazuhito Nomura et al.
Scientific reports, 10(1), 15834-15834 (2020-09-29)
Whether central apnoea or hypopnoea can be induced by organophosphorus poisoning remains unknown to date. By using the acute brainstem slice method and multi-electrode array system, we established a paraoxon (a typical acetylcholinesterase inhibitor) poisoning model to investigate the time-dependent
Kevin G McGarry et al.
Toxicological sciences : an official journal of the Society of Toxicology, 174(1), 124-132 (2019-12-28)
Organophosphorus (OP) compounds, which include insecticides and chemical warfare nerve agents (CWNAs) such as sarin (GB) and VX, continue to be a global threat to both civilian and military populations. It is widely accepted that cholinesterase inhibition is the primary
Lorise C Gahring et al.
American journal of physiology. Lung cellular and molecular physiology, 319(4), L683-L692 (2020-07-30)
Nicotine of unprecedented concentrations and purity is being inhaled by those using commercially available electronic nicotine delivery systems (ENDS). The consequences of this route of self-administration on the immunological response to inhaled allergens are not known. In mice, sensitization and
Sílvia Sisó et al.
Toxicological sciences : an official journal of the Society of Toxicology, 157(2), 330-341 (2017-03-23)
Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). However, in contrast to the OP nerve agents, the long-term consequences of DFP-induced SE are not well
Zhao Wei et al.
Bioorganic & medicinal chemistry, 25(16), 4497-4505 (2017-07-08)
A new family of nonquaternary reactivators for nerve agent-inhibited human acetylcholinesterase (hAChE) were designed, synthesized and tested in this paper. It was found that salicylaldoximes were able to quickly cleave the P-S bond of organophosphate and avoid the reinhibition phenomenon
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