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Merck
CN
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文件

P57204

Sigma-Aldrich

哒嗪

98%

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别名:
1,2-Diazabenzene, 1,2-Diazine, o-Diazine
经验公式（希尔记法）:
C4H4N2
CAS号:
289-80-5
分子量:
80.09
Beilstein:
103906
EC 号:
206-025-5
MDL编号:
MFCD00006463
UNSPSC代码:
12352100
PubChem化学物质编号:
24898697
NACRES:
NA.22

质量水平

100

检测方案

98%

折射率

n20/D 1.524 (lit.)

bp

208 °C (lit.)

mp

−8 °C (lit.)

密度

1.103 g/mL at 25 °C (lit.)

SMILES字符串

c1ccnnc1

InChI

1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H

InChI key

PBMFSQRYOILNGV-UHFFFAOYSA-N

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相关类别

一般描述

哒嗪是一种单碱式1,2-二嗪化合物，通常可通过1,4-二羰基与肼反应进行制备。哒嗪环存在于如克雷达嗪、吡哆醇等多种除草剂，以及如头孢唑仑、奥拉帕利、他拉唑帕利和卡达拉嗪等多种药物中。

应用

哒嗪可用于：
  • 作为构建单元，用于合成可作为GSK-3抑制剂的N-苯基-4-吡唑并[1,5-b]哒嗪-3-基-嘧啶-2-胺衍生物。
  • 作为合成具有重要药用价值的吡咯并[1,2-b]哒嗪衍生物的起始材料。
  • 在酸性条件下制备可作为钢铁缓蚀剂的1-（6-乙氧基-6-氧代己基）哒嗪-1-溴化铵和1-（2-溴乙酰基）哒嗪溴化铵离子液体。

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Dorina Mantu et al.
European journal of medicinal chemistry, 45(11), 5164-5168 (2010-09-04)
A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds
Timothy D Scarborough et al.
The Journal of chemical physics, 136(5), 054309-054309 (2012-02-11)
We report on the ultrafast photoionization of pyridine, pyridazine, pyrimidine, and pyrazine. These four molecules represent a systematic series of perturbations into the structure of a benzene ring which explores the substitution of a C-H entity with a nitrogen atom
Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
Popovici L, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 230-243 (2019)
Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules
He Z-X, et al.
European Journal of Medicinal Chemistry, 112946-112946 (2020)
Pyridazinium-based ionic liquids as novel and green corrosion inhibitors of carbon steel in acid medium: electrochemical and molecular dynamics simulation studies
El-Hajjaji F, et al.
Journal of Molecular Liquids, 249(1), 997-1008 (2018)
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