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质量水平
检测方案
99%
形式
crystals
bp
165 °C/10 mmHg (lit.)
mp
49-51 °C (lit.)
SMILES字符串
OC(=O)CCCc1ccccc1
InChI
1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)
InChI key
OBKXEAXTFZPCHS-UHFFFAOYSA-N
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一般描述
4-苯丁酸(4-PBA)可用于治疗尿素循环代谢障碍。
应用
4-PBA已被用作内质网应激(ERS)的选择性抑制剂。
还可用作合成以下物质的反应剂：
还可用作合成以下物质的反应剂：
- 使用路易斯酸催化剂的1-四氢萘酮。
- 4,N-二苯基丁酰胺。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
Kolb PS, et al.
The International Journal of Biochemistry & Cell Biology, 61, 45-52 (2015)
Induction of apoptosis coupled to endoplasmic reticulum stress through regulation of CHOP and JNK in bone marrow mesenchymal stem cells from patients with systemic lupus erythematosus
Guo G, et al.
Journal of immunology research (2015)
Synthesis of 1-tetralones by intramolecular Friedel?Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts
Cui DM, et al.
Tetrahedron Letters, 44(21), 4007-4010 (2003)
Clean, reusable and low cost heterogeneous catalyst for amide synthesis
Comerford JW, et al.
Chemical Communications (Cambridge, England), 18(21), 2562-2564 (2009)
Karin Eigner et al.
Scientific reports, 7(1), 17498-17498 (2017-12-14)
The mechanisms hallmarking melanoma progression are insufficiently understood. Here we studied the impact of the unfolded protein response (UPR) - a signalling cascade playing ambiguous roles in carcinogenesis - in melanoma malignancy. We identified isogenic patient-derived melanoma cell lines harboring
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