P14815
4-乙氧基苯胺
98%
别名:
对氨基苯乙醚, 4-乙氧基苯胺
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关于此项目
线性分子式:
C2H5OC6H4NH2
化学文摘社编号:
分子量:
137.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
205-855-5
Beilstein/REAXYS Number:
606666
MDL number:
Assay:
98%
InChI key
IMPPGHMHELILKG-UHFFFAOYSA-N
InChI
1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3
SMILES string
CCOc1ccc(N)cc1
assay
98%
Quality Level
refractive index
n20/D 1.559 (lit.)
bp
250 °C (lit.)
mp
2-5 °C (lit.)
density
1.065 g/mL at 25 °C (lit.)
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
251.6 °F - closed cup
flash_point_c
122 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
T Lindqvist et al.
Pharmacology & toxicology, 69(2), 117-121 (1991-08-01)
The toxicity of some metabolic products pertinent to 4-ethoxyaniline in isolated hepatocytes were investigated. The compounds investigated were 4-ethoxynitrosobenzene (1), 4-ethoxy-4'-nitrosodiphenylamine (2), 3,6-bis(4-ethoxy-phenylimino)-4-ethoxy-1,4-cyclohexadienylamine (3), 4-(4-ethoxyphenylimino)-2,3-dimethyl-2,5-cyclohexadiene-1-one (4) and 4-(4-ethoxyphenylimino)-2,6-dimethyl-2,5-cyclohexadiene-1-one (5). Of these, 1, 2 and 3 are oxidation products of 4-ethoxyaniline.
C B Jensen et al.
Toxicology and applied pharmacology, 111(1), 1-12 (1991-10-01)
Phenacetin is well known to cause hemolytic anemia and methemoglobinemia in humans. Early mechanistic studies clearly established a causal role for active/reactive drug metabolites in the process but did not unequivocally identify these metabolite(s) or resolve the question of whether
E C McCoy et al.
Mutation research, 173(4), 245-250 (1986-04-01)
Two mutagenic metabolites of phenacetin, p-nitrosophenetol and N-hydroxy-p-phenetidine, were tested in S. typhimurium strains TA100, its nitroreductase-deficient derivative TA100NR, and O-acetylase-deficient strains TA100 Tn5-1,8-DNP1011 and -DNP1012 in the presence or absence of an exogenous metabolic activation system. The results indicate
Morena Gabriele et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(9), 961-965 (2019-06-27)
Human arylacetamide deacetylase (AADAC) is a single microsomal serine esterase involved in the hydrolysis of many acetyl-containing drugs. To date, the presence and activity of the AADAC enzyme in human lungs has been scarcely examined. We investigated its gene and
Esko Kankuri et al.
Thrombosis research, 110(5-6), 299-303 (2003-11-01)
The present study was aimed to test the possible cyclooxygenase (COX)-1/COX-2 selectivity of the old analgesic drug phenacetin and its metabolite p-phenetidine, which exhibits high renal toxicity. Paracetamol (acetaminophen), the main metabolite of phenacetin with low renal toxicity, and indomethacin
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