P1101
D-青霉胺二硫化物
97%, cell analysis
别名:
3,3′-二硫代双(2-氨基-3-甲基丁酸), S,S′-二(D-青霉胺), 二硫青霉胺
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关于此项目
线性分子式:
[-SC(CH3)2CH(NH2)CO2H]2
化学文摘社编号:
分子量:
296.41
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
244-107-2
MDL number:
Beilstein/REAXYS Number:
4461521
产品名称
D-青霉胺二硫化物, 97%
InChI
1S/C10H20N2O4S2/c1-9(2,5(11)7(13)14)17-18-10(3,4)6(12)8(15)16/h5-6H,11-12H2,1-4H3,(H,13,14)(H,15,16)/t5-,6-/m0/s1
InChI key
POYPKGFSZHXASD-WDSKDSINSA-N
SMILES string
CC(C)(SSC(C)(C)[C@@H](N)C(O)=O)[C@@H](N)C(O)=O
assay
97%
form
powder or crystals
optical activity
[α]25/D −75°, c = 1 in 1 M NaOH
reaction suitability
reaction type: solution phase peptide synthesis
color
white
mp
204 °C (dec.) (lit.)
application(s)
cell analysis
Quality Level
Application
Used in pharmacological studies of:
- Molecules dermatomyositis activity
- Antimelanoma activity of apoptogenic carbonyl scavengers
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
F Matthey et al.
Clinical nephrology, 25(5), 268-271 (1986-05-01)
D-penicillamine and its major metabolites cysteine-penicillamine disulphide (CP) and penicillamine disulphide (P2) concentrations were measured in plasma from a hemodialysis patient with rheumatoid arthritis. CP and P2 alone were measured in plasma and a plasma ultrafiltrate from a second patient.
G Carruthers et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 7(1), 35-40 (1984-01-01)
The pharmacokinetic disposition of D-penicillamine and its major metabolites, penicillamine cysteine disulfide ( PSSC ) and penicillamine disulfide ( PSSP ) has been studied in eight patients with rheumatoid arthritis. Plasma concentrations of D-penicillamine, PSSP and PSSC displayed similar characteristics
Quantification of pipecolic acid in plasma, and of urinary cystine in the presence of penicillamine-cystine disulfide, with the Beckman 6300 amino acid analyzer.
J Wong et al.
Clinical chemistry, 33(7), 1302-1303 (1987-07-01)
Y J Yang et al.
Occupational and environmental medicine, 51(4), 267-270 (1994-04-01)
Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical features and increased urinary
J C Crawhall
Clinical and investigative medicine. Medecine clinique et experimentale, 7(1), 31-34 (1984-01-01)
Penicillamine disulfides have been analysed by automatic amino acid analysis. Because the free thiol reacts poorly with ninhydrin, other detection methods are preferred, particularly high pressure liquid chromatography using an electrochemical detector or gas chromatography with a flame ionization detector.
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