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Merck
CN

N8141

Sigma-Aldrich

4-硝基喹啉 N -氧化物

≥98%

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别名:
1-氧化-4-硝基喹啉, 4-NQO
经验公式(希尔记法):
C9H6N2O3
CAS号:
分子量:
190.16
Beilstein:
165756
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

检测方案

≥98%

颜色

yellow to brown

mp

154-156 °C (lit.)

溶解性

acetone: soluble, clear to hazy

储存温度

−20°C

SMILES字符串

[O-][N+](=O)c1cc[n+]([O-])c2ccccc12

InChI

1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H

InChI key

YHQDZJICGQWFHK-UHFFFAOYSA-N

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一般描述

4-硝基喹啉N-氧化物是一种广泛应用于化学研究和开发的喹啉衍生物。

应用

4-硝基喹啉 N-氧化物已被用作模型化合物以研究其致癌作用。

生化/生理作用

在试验条件下可诱发皮肤和肺肿瘤。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Carc. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
Williams AB, et al.
DNA Repair, 9(10), 1090-1097 (2010)
Antitumor activity of ficus deltoidea extract on oral cancer: An in vivo study
Al-Koshab M, et al.
Journal of Oncology, 2020 (2020)
Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
J Peter Svensson et al.
PloS one, 7(5), e37368-e37368 (2012-05-23)
Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized that human orthologs of these S. cerevisiae proteins would also be required for cellular survival after treatment with DNA damaging agents.

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