N22908
3-硝基丙酸
97%
别名:
β-硝基丙酸, 3-硝基丙酸, 杀牛型结核菌素, 风车藤酸
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关于此项目
线性分子式:
O2N(CH2)2CO2H
化学文摘社编号:
分子量:
119.08
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
EC Number:
208-003-0
Beilstein/REAXYS Number:
1759889
MDL number:
Assay:
97%
Form:
crystals
Biochem/physiol Actions
兴奋性神经毒素，证明可引起类似于 Huntington 疾病的脑损伤。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Samantha Corrà et al.
iScience, 26(10), 107955-107955 (2023-10-09)
Mutations in MPV17 are a major contributor to mitochondrial DNA (mtDNA) depletion syndromes, a group of inherited genetic conditions due to mtDNA instability. To investigate the role of MPV17 in mtDNA maintenance, we generated and characterized a Drosophila melanogaster Mpv17
Wang-Tso Lee et al.
Progress in neurobiology, 72(2), 87-110 (2004-04-06)
Huntington's disease (HD) is an inherited neurodegenerative disease, in which there is progressive motor and cognitive deterioration, and for which the pathogenesis of neuronal death remains controversial. Mitochondrial toxins like 3-nitropropionic acid (3-NP) and malonate, functioning as the inhibitors of
Rajat Sandhir et al.
Biochimica et biophysica acta, 1832(3), 421-430 (2012-12-12)
The study was designed to investigate the beneficial effect of quercetin supplementation in 3-nitropropionic acid (3-NP) induced model of Huntington's disease (HD). HD was induced in rats by administering sub-chronic dose of 3-NP, intraperitoneally, twice daily for 17days. Quercetin was
Esther T Menze et al.
Neurotoxicology, 33(5), 1265-1275 (2012-08-02)
Huntington's disease (HD) is a progressive neurodegenerative disorder with a spectrum of cognitive, behavioral, and motor abnormalities. The mitochondrial toxin 3-nitropropionic acid (3-NP) effectively induces specific behavioral changes, primarily manifested as prepulse inhibition (PPI) deficit of acoustic startle stimuli, and
Tohru Yamamori et al.
Free radical biology & medicine, 53(2), 260-270 (2012-05-15)
Whereas ionizing radiation (Ir) instantaneously causes the formation of water radiolysis products that contain some reactive oxygen species (ROS), ROS are also suggested to be released from biological sources in irradiated cells. It is now becoming clear that these ROS
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