N1280
去甲氯米帕明 盐酸盐
≥98% (TLC), powder
别名:
N-去甲氯丙咪嗪
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关于此项目
经验公式（希尔记法）:
C18H21ClN2 · HCl
化学文摘社编号:
分子量:
337.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥98% (TLC)
Form:
powder
InChI key
KMDDAZOLOSKTKZ-UHFFFAOYSA-N
SMILES string
Cl.CNCCCN1c2ccccc2CCc3ccc(Cl)cc13
InChI
1S/C18H21ClN2.ClH/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21;/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3;1H
assay
≥98% (TLC)
form
powder
color
white to yellow
Quality Level
Biochem/physiol Actions
三环抗抑郁剂；氯米帕明的活性代谢物，优先阻断去甲肾上腺素转运体。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
K Fujita et al.
European journal of pharmacology, 204(3), 227-233 (1991-11-12)
When rats received a single i.p. injection of clomipramine (20 mg/kg), clomipramine and desmethylclomipramine were rapidly distributed into the brain and their concentrations were markedly higher in the brain than in the serum, while the concentration of the metabolite in
Plasma concentrations after a clomipramine intoxication.
L M Stolk et al.
Journal of analytical toxicology, 22(7), 612-613 (1998-12-10)
T Marcourakis et al.
Journal of psychopharmacology (Oxford, England), 13(1), 40-44 (1999-04-30)
Several placebo-controlled trials have shown the efficacy of clomipramine (CMI) in panic disorder. However, none has investigated the relationship between CMI, and desmethylclomipramine (DCMI) plasma levels, and outcome. In this trial, 41 patients meeting the DSM-III-R criteria for panic disorder
L Palego et al.
Therapeutic drug monitoring, 22(2), 190-194 (2000-04-25)
A simple reversed-phase liquid chromatographic method enabling the simultaneous analysis in plasma of the tricyclic antidepressant clomipramine, its demethylated metabolite, and the selective serotonin reuptake inhibitor fluvoxamine, was developed. The drugs and dibenzepine, the internal standard, were extracted from 1
R de la Torre et al.
Therapeutic drug monitoring, 20(3), 340-346 (1998-06-19)
An analytical method for the simultaneous determination of amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, and desmethylclomipramine in human plasma using promazine as internal standard is described. The method is based on a solid-phase extraction procedure using the Bond-Elut TCA columns followed
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