推荐产品
质量水平
检测方案
≥98% (TLC)
形式
powder
颜色
white to yellow
SMILES字符串
Cl.CNCCCN1c2ccccc2CCc3ccc(Cl)cc13
InChI
1S/C18H21ClN2.ClH/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21;/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3;1H
InChI key
KMDDAZOLOSKTKZ-UHFFFAOYSA-N
生化/生理作用
三环抗抑郁剂;氯米帕明的活性代谢物,优先阻断去甲肾上腺素转运体。
警示用语:
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Psychopharmacology, 117(2), 149-153 (1995-01-01)
The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in
European journal of pharmacology, 204(3), 227-233 (1991-11-12)
When rats received a single i.p. injection of clomipramine (20 mg/kg), clomipramine and desmethylclomipramine were rapidly distributed into the brain and their concentrations were markedly higher in the brain than in the serum, while the concentration of the metabolite in
Biological psychiatry, 59(3), 287-290 (2005-11-08)
The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited investigations that have sought to quantify fetal exposure. Maternal and umbilical cord sera were collected at delivery from ten women taking nortriptyline and seven taking
Psychopharmacology, 216(2), 279-286 (2011-02-22)
Norepinephrine transporter (NET) is one of the key targets for antidepressants such as combined serotonin and norepinephrine reuptake inhibitors as well as some of the tricyclic antidepressants. Clomipramine, a tricyclic antidepressant, has been reported to have an active metabolite, desmethylclomipramine
Progress in neuro-psychopharmacology & biological psychiatry, 25(3), 519-533 (2001-05-24)
1. The authors present here a sensitive and rapid reversed-phase liquid chromatographic method which enables the simultaneous analysis in plasma of two different drugs and their metabolites: the atypical neuroleptic clozapine and the tricyclic antidepressant clomipramine. 2. Samples and the
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