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反应适用性
reagent type: cross-linking reagent
溶解性
chloroform: 50 mg/mL
DMF: soluble
储存温度
2-8°C
SMILES字符串
O=C1C=CC(=O)N1c2ccc(cc2)C(=O)c3ccccc3
InChI
1S/C17H11NO3/c19-15-10-11-16(20)18(15)14-8-6-13(7-9-14)17(21)12-4-2-1-3-5-12/h1-11H
InChI key
OZIZEXQRIOURIJ-UHFFFAOYSA-N
应用
含巯基特异性基团和光敏基团的双异官能化交联剂。通常,初始反应在 pH 为 6.8 (6.5-7.0) 时通过硫醚偶联至含游离巯基的分子。紫外光 (250nm) 照射的过程中通过双自由基激发态发生二次键合。二苯甲酮对 C-H 插入表现出更大的特异性并且在水中比类似试剂更稳定。一般说来,它们附接更有效,因为可对其反复照射;然而可能需要更强的照射。与类似试剂相比,二苯甲酮对还原反应不敏感。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
FEBS letters, 301(1), 99-102 (1992-04-13)
It has been shown that the EGTA-resistant actin, one of the two actin molecules associated to gelsolin, can be predominantly cross-linked to gelsolin by benzophenone-4-maleimide (BPM), a photoaffinity-labeling reagent, which was conjugated to Cys-374 of actin prior to cross-linking (Doi
The Journal of biological chemistry, 280(30), 27896-27903 (2005-06-14)
The vacuolar (H+)-ATPases (V-ATPases) are multisubunit complexes responsible for ATP-dependent proton transport across both intracellular and plasma membranes. The V-ATPases are composed of a peripheral domain (V1) that hydrolyzes ATP and an integral domain (V0) that conducts protons. Dissociation of
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To attain light-dependent functionalization of biocompatible materials, a photolabel-derivatized, bioactive laminin fragment has been synthesized, chemically characterized, and photoimmobilized. Covalent high-resolution patterning of the laminin fragment CDPGYIGSR to hydroxylated fluorinated ethylene propylene (FEP-OH), poly(vinyl alcohol), and glycophase glass has been
The Biochemical journal, 296 ( Pt 3), 577-583 (1993-12-15)
Treatment of murine leukaemia virus reverse transcriptase with benzophenone 4-maleimide inactivates DNA polymerase activity, but has no effect on the RNAase H function. Kinetic measurements indicated that benzophenone 4-maleimide is a competitive inhibitor with respect to template-primer binding, but is
Journal of molecular biology, 296(3), 899-910 (2000-03-15)
The interaction sites of rabbit skeletal troponin I (TnI) with troponin C (TnC), troponin T (TnT), tropomyosin (Tm) and actin were mapped systematically using nine single cysteine residue TnI mutants with mutation sites at positions 6, 48, 64, 89, 104
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