K6000
α-酮-γ-甲硫基丁酸 钠盐
≥97%
别名:
4-甲硫基-2-氧丁酸 钠盐, 4-甲硫基-2-氧代丁酸 钠盐, KMBA
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关于此项目
线性分子式:
C5H7O3SNa
化学文摘社编号:
分子量:
170.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥97%
InChI
1S/C5H8O3S.Na/c1-9-3-2-4(6)5(7)8;/h2-3H2,1H3,(H,7,8);/q;+1/p-1
SMILES string
[Na].CSCCC(=O)C(O)=O
InChI key
IFSCKRWNXKWTLR-UHFFFAOYSA-M
assay
≥97%
storage temp.
2-8°C
Quality Level
General description
α-酮-γ-甲硫丁酸(KMTB)是L-甲硫氨酸的酮衍生物，作为L-甲硫氨酸的替代物具有较大潜力。KMTB的钠盐可用于亲核取代反应。还可作为合成砌块制备氨基酸、多肽等复杂有机物。
Application
- 采用ORAC和TOSC法测定抗氧化能力。本研究详细介绍了α-酮-γ(甲硫基)丁酸钠盐在ORAC和TOSC测定法评估抗氧化能力中的应用，强调了其在代谢和化学合成研究中的作用（Garrett AR et al., 2010）。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
F Regoli et al.
Toxicology and applied pharmacology, 156(2), 96-105 (1999-04-13)
We have extended the application of our previously reported total oxidant scavenging capacity (TOSC) assay (Winston et al., Free Radical Biol. Med. 24, 480-493, 1998) to permit facile quantification of the absorbance capacity of antioxidants toward three potent oxidants, i.e.
Gary W Winston et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 139(4), 281-288 (2005-02-03)
During embryogenesis in grass shrimp the capacity to scavenge oxyradicals increased as measured by the Total Oxyradical Scavenging Capacity (TOSC) assay. The increase in TOSC during embryogenesis was associated with increasing concentrations of a number of antioxidants, including coenzyme Q
Charlotte Sandersen et al.
Veterinary anaesthesia and analgesia, 38(2), 83-93 (2011-02-10)
To investigate the effect of acepromazine (ACP) on reactive oxygen species (ROS) production by stimulated equine neutrophils. Ex vivo biochemical experiments. Isolated neutrophils from healthy untreated horses. Neutrophils were incubated with ACP at concentrations of 10(-4), 10(-5) or 10(-6) M
Michael W Straza et al.
Cell cycle (Georgetown, Tex.), 9(18), 3740-3750 (2010-10-12)
The CtBP transcriptional corepressors promote cancer cell survival and migration/invasion. CtBP senses cellular metabolism via a regulatory dehydrogenase domain, and is antagonized by p14/p19(ARF) tumor suppressors. The CtBP dehydrogenase substrate 4-methylthio-2-oxobutyric acid (MTOB) can act as a CtBP inhibitor at
Manas K Chattopadhyay et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(45), 16158-16163 (2005-11-02)
Methylthioadenosine is formed during the biosynthesis of spermidine and of spermine and is metabolized by methylthioadenosine phosphorylase, an enzyme missing in several tumor cell lines. In Saccharomyces cerevisiae, this enzyme is coded by the MEU1 gene. We have now studied
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