质量水平
检测方案
≥97%
形式
powder
储存温度
−20°C
SMILES字符串
N.OCC(O)C1OC(O)(CC(O)C1O)C(O)=O
InChI
1S/C8H14O8.H3N/c9-2-4(11)6-5(12)3(10)1-8(15,16-6)7(13)14;/h3-6,9-12,15H,1-2H2,(H,13,14);1H3
InChI key
UDJBBKGYARWWNJ-UHFFFAOYSA-N
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应用
- KDO类似物的合成:研究3-脱氧-D-甘露-辛酮糖酸(KDO)类似物的合成,包括2-酮基-3-脱氧辛酮酸铵盐。这些类似物是CMP-KDO合成酶的潜在抑制剂,对于开发治疗细菌感染的新药十分重要,有助于加强对细菌脂多糖合成的了解(Luthman et al., 1987)。
生化/生理作用
KDO 是一种唾液酸,是细菌脂多糖的成分以及抗生素研发的可用靶标。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Current drug discovery technologies, 6(1), 19-33 (2009-03-12)
Despite important advances made in the last century, infectious diseases caused by pathogenic microrganisms are still a major threat to human health. This is worsened by the occurrence of new forms of bacterial resistance against antibiotics, that are the main
Frontiers in cellular and infection microbiology, 9, 177-177 (2019-06-14)
Campylobacter jejuni outer membrane vesicles (OMVs) contain numerous virulence-associated proteins including the cytolethal distending toxin and three serine proteases. As C. jejuni lacks the classical virulence-associated secretion systems of other enteric pathogens that deliver effectors directly into target cells, OMVs
PloS one, 6(4), e19003-e19003 (2011-05-06)
Francisella tularensis is a category-A select agent and is responsible for tularemia in humans and animals. The surface components of F. tularensis that contribute to virulence are not well characterized. An electron-dense capsule has been postulated to be present around
Food research international (Ottawa, Ont.), 96, 235-243 (2017-05-22)
The effect of egg albumin fining, progressive clarification and cross-flow microfiltration on the polysaccharide and proanthocyanidin composition of four red varietal wines was studied in this work. Discriminant analyses were applied to achieve a possible differentiation of the wines according
PloS one, 7(4), e32359-e32359 (2012-04-13)
We previously reported that neuraminidase (NA) pretreatment of human PBMCs markedly increased their cytokine response to lipopolysaccharide (LPS). To study the mechanisms by which this occurs, we transfected HEK293T cells with plasmids encoding TLR4, CD14, and MD2 (three components of
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