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形式
powder
质量水平
反应适用性
reagent type: cross-linking reagent
溶解性
DMF: 50 mg/mL
应用
peptide synthesis
官能团
NHS ester
储存温度
−20°C
SMILES字符串
O=C(N1OC(CI)=O)CCC1=O
InChI
1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
InChI key
VRDGQQTWSGDXCU-UHFFFAOYSA-N
应用
具有氨基和巯基反应性的双异官能团交联剂。典型情况下，最初通过 pH 7.5 (6.5-8.5) 缓冲条件下的酰胺键偶联到含有伯胺的分子上，接着通过 pH 7.5 (7.0-8.0) 缓冲条件下的硫醚链与含有自由巯基的分子进行特异性次级键合。用于制备酶免疫交联剂和半抗原载体分子偶联物。提供两个原子的连接基。
注意
碘乙酰基具有光敏性。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
G Houen et al.
Journal of immunological methods, 181(2), 187-200 (1995-04-26)
Two methods for the preactivation of proteins and conjugation of peptides to proteins under mild conditions are presented. Preactivation of proteins with divinylsulfone (DVS) permits peptide conjugation through either amino, hydroxyl or sulphydryl groups depending on the coupling pH used
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