质量水平
检测方案
97%
mp
>300 °C (lit.)
SMILES字符串
OC(=O)C1CCNCC1
InChI
1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
InChI key
SRJOCJYGOFTFLH-UHFFFAOYSA-N
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应用
用于合成以下物质的反应物：
- 用于组织蛋白酶 B 抑制的抗生素硝酰基衍生物
- 1-磷酸鞘氨醇受体激动剂
- 心血管疾病治疗的 RhoA 抑制剂
- 烷基哌啶和哌嗪异羟肟酸作为 HDAC 抑制剂
- CHK1 抑制剂
- 用于类风湿性关节炎治疗研究的 IKK2 抑制剂
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Alicja Nowaczyk et al.
Journal of molecular graphics & modelling, 85, 171-181 (2018-09-17)
Inhibition of 4-aminobutanoic acid (GABA) uptake is a strategy for enhancing GABA transmission. The utility of this approach is demonstrated by the successful development of such agents for the treatment of epilepsy and pain. Existing reports on acute brain slice
Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice.
Jenna Elizabeth Hunt et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(5), G980-G987 (2020-04-21)
Glucagon-like peptide (GLP)-1 and -2-secreting L cells have been shown to express the bile acid receptor Takeda G protein-receptor-5 (TGR5) and increase secretion upon receptor activation. Previous studies have explored GLP-1 secretion following acute TGR5 activation, but chronic activation and
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic
Michela Semeraro et al.
Clinica chimica acta; international journal of clinical chemistry, 440, 108-112 (2014-12-03)
Pipecolic acid (PA) is an important biochemical marker for the diagnosis of peroxisomal disorders. PA is also a factor responsible for hepatic encephalopathy and a possible biomarker for pyridoxine-dependent seizures. We developed an easy and rapid PA quantification method, by
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
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