H146
4-羟基美芬妥英
≥98% (HPLC)
别名:
(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮
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关于此项目
经验公式（希尔记法）:
C12H14N2O3
化学文摘社编号:
分子量:
234.25
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥98% (HPLC)
InChI
1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
SMILES string
CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
InChI key
OQPLORUDZLXXPD-UHFFFAOYSA-N
assay
≥98% (HPLC)
solubility
DMSO: >5 mg/mL
Quality Level
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General description
美芬妥英的 YP2C19 代谢物。
Application
药理活性研究：
用于电子捕获气相色谱法的分析物
- 药物对代谢的影响
- 体外微粒体细胞色素P450活性
用于电子捕获气相色谱法的分析物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M. Salsali, et al.,
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The 5HT(1A) receptor agonist sarizotan is in clinical development for the treatment of dyskinesia, a potentially disabling complication in Parkinson's disease. We investigated the effect of sarizotan on the clinical pharmacokinetics of probe drugs for cytochrome P450 (CYP) to evaluate
Xunge Zhang et al.
Pharmaceutical biology, 58(1), 247-252 (2020-04-01)
Context: Cepharanthine (CEP) extracted from the roots of Stephania cepharantha Hayata (Menispermaceae), has a range of therapeutic potential in clinical conditions. Whether it affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear.Materials and methods: The effects of
J Caslavska et al.
Journal of chromatography. B, Biomedical applications, 656(1), 219-231 (1994-06-03)
Phenotypes for hydroxylation can be predicted by using mephenytoin and dextromethorphan as substrates, whereas phenotypes for acetylation can be determined with caffeine as probe drug. After single-dose administration of one of these drugs, of two of them simultaneously, or of
Xiao-Ping Chen et al.
Clinical pharmacology and therapeutics, 73(3), 264-271 (2003-03-07)
This study was designed to define the effect of low-dose aspirin administration on the activity of cytochrome P450 (CYP) in normal human subjects. Aspirin, 50 mg daily, was given for 14 days to 18 nonsmoking healthy male volunteers. A modified
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