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Merck
CN
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文件

G8503

Sigma-Aldrich

18α-甘草次酸

≥95%

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别名:
18α-甘草次酸, 18-异甘草次酸, 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid
经验公式（希尔记法）:
C30H46O4
CAS号:
1449-05-4
分子量:
470.68
EC 号:
215-907-9
MDL编号:
MFCD00064897
UNSPSC代码:
12352115
PubChem化学物质编号:
57654221
NACRES:
NA.22

质量水平

100

检测方案

≥95%

SMILES字符串

[H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

InChI key

MPDGHEJMBKOTSU-PMTKVOBESA-N

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相关类别

一般描述

18α-甘草次酸 (18α-GA) 是一种在甘草中发现的具有生物活性的三萜类化合物。其显示对 11-HSD1（11-羟基类固醇脱氢酶 1）的选择性抑制。其对肝星状细胞 (HSC) 也有抗增殖和凋亡作用。

应用

18α-甘草次酸可用于合成：
  • 3-酮-18α-甘草次酸
  • 18α-甘草次酸甲酯
  • 3-酮基-18α-甘草次酸甲酯

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

预防措施声明

P301 + P312 + P330

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Product G8503, 18α-Glycyrrhetinic acid?

    It is soluble in chloroform:ethanol (2:3) at a concentration of 20 mg/mL.  It is expected to be soluble in dimethyl sulfoxide (DMSO) as well.

  4. What is the stability of Product G8503, 18α-Glycyrrhetinic acid, once in solution? 

    Unfortunately, we don't have any solution stability data available for this product.  

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Sebastian M Goerke et al.
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Neovascularization represents an important issue in tissue-engineering applications, since survival of implanted cells strongly relies on sufficient oxygen and nutrient supply. We have recently observed that human bone marrow-derived mesenchymal stem cells (MSCs) support neovessel formation originating from coimplanted endothelial
Selective inhibition of 11?-hydroxysteroid dehydrogenase 1 by 18a-glycyrrhetinic acid but not 18?-glycyrrhetinic acid.
Classen-Houben D, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 113(3), 248-252 (2009)
18a-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line.
Zong L, et al.
Journal of Digestive Diseases, 14(6), 328-336 (2013)
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