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主要文件

F5062

Sigma-Aldrich

Fmoc-Lys(Me)3-OH Chloride

≥97%, for peptide synthesis

别名:

Fmoc-Lys(Me3Cl)-OH, N-alpha-Fmoc-N-alpha-trimethyl-N-L-lysine · chloride

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About This Item

经验公式(希尔记法):
C24H31ClN2O4
分子量:
446.97
MDL编号:
UNSPSC代码:
12352209
NACRES:
NA.26

产品名称

Fmoc-Lys(Me)3-OH Chloride, ≥97%

质量水平

方案

≥97%

表单

liquid

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

应用

peptide synthesis

官能团

Fmoc

运输

dry ice

储存温度

−20°C

SMILES字符串

Cl.[N+](CCCC[C@H](N=C([O-])OCC1c2c(cccc2)c3c1cccc3)C(=O)O)(C)(C)C

InChI

1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1

InChI key

XUJRNPVABVHOAJ-FTBISJDPSA-N

一般描述

Fmoc protected N-trimethyl lysine

应用

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:
  • Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.
  • Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.
  • Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Multifunctional Reagents for Quantitative Proteome?Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development.
Broncel M, et al.
Angewandte Chemie (International Edition in English), 54(20), 5948-5951 (2015)
Sequential Peptide Ligation by Combining the Cys?Pro Ester (CPE) and Thioester Methods and Its Application to the Synthesis of Histone H3 Containing a Trimethyl Lysine Residue.
Kawakami T, et al.
Bulletin of the Chemical Society of Japan, 86(6), 690-697 (2013)
Novel peptide linkers for highly potent antibody? auristatin conjugate.
Doronina S O, et al.
Bioconjugate Chemistry, 19(10), 1960-1963 (2008)

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