推荐产品
检测方案
97%
mp
205-208 °C (lit.)
SMILES字符串
CCOC(=O)c1c(C)[nH]c2ccc(O)cc12
InChI
1S/C12H13NO3/c1-3-16-12(15)11-7(2)13-10-5-4-8(14)6-9(10)11/h4-6,13-14H,3H2,1-2H3
InChI key
BSNHKSUAAMJXBB-UHFFFAOYSA-N
应用
Reactant for preparation of:
- Potential anti-inflammatory and analgesic agents
- Histamine-3 receptor inverse agonists for the treatment of obesity
- Tubulin Polymerization Inhibitors
- 4,7-dioxoindole-3-methyl prodrugs
- Antagonists at M4 muscarinic receptors
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Badiger, J.; et al.
ARKIVOC (Gainesville, FL, United States), 217-217 (2009)
Ferrer, S.; et al.
Tetrahedron, 59, 3445-3445 (2003)
Pascale David Pierson et al.
Journal of medicinal chemistry, 52(13), 3855-3868 (2009-05-22)
Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H(3)R) in
Thomas M Böhme et al.
Journal of medicinal chemistry, 45(14), 3094-3102 (2002-06-28)
Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selectivity at that time. However, several newly synthesized compounds exhibit a
Jing-Ping Liou et al.
Journal of medicinal chemistry, 51(14), 4351-4355 (2008-07-01)
1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 50 of 0.9 and 0.6 microM, respectively, exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin
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