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安全信息

E004

Sigma-Aldrich

3-羟甲基-β-咔啉

别名:

3-HMC

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About This Item

经验公式（希尔记法）:
C12H10N2O
CAS号:
65474-79-5
分子量:
198.22
MDL编号:
MFCD00055074
UNSPSC代码:
12352100
PubChem化学物质编号:
329798936
NACRES:
NA.22

表单

solid

质量水平

200

mp

215-219 °C

SMILES字符串

OCc1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C12H10N2O/c15-7-8-5-10-9-3-1-2-4-11(9)14-12(10)6-13-8/h1-6,14-15H,7H2

InChI key

CPBYHTDUBNSBQM-UHFFFAOYSA-N

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

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B Krespan et al.
Brain research, 295(2), 265-274 (1984-03-19)
The actions of the benzodiazepine (BDZ) antagonists 3-hydroxymethyl-beta-carboline (3-HMC), Ro 14-7437 and Ro 15-1788 were tested on single cell activity of rat hypothalamic neurons in tissue cultures and on membrane properties of CA1 hippocampal pyramidal neurons in transverse slices. In
N Naughton et al.
Life sciences, 36(23), 2239-2245 (1985-06-10)
It is reported that benzodiazepines such as diazepam will stimulate the opiate receptor system and that B-carboline drugs, which are benzodiazepine antagonists, may interact with opiate receptors directly. The ability of 3-hydroxymethyl-B-carboline (3-HMC) to antagonize several parameters of fentanyl anesthesia
W B Mendelson
Psychiatric developments, 2(3), 161-177 (1984-01-01)
The discovery of high affinity, stereoselective binding sites for benzodiazepines (BZ) was a major step in understanding the molecular mechanism by which these widely used sedative/hypnotics exert their various pharmacologic effects. It has become clear that the BZ receptor complex
H E Shannon et al.
The Journal of pharmacology and experimental therapeutics, 246(1), 275-281 (1988-07-01)
Rats were trained to discriminate between saline and 1.0 mg/kg of diazepam in a two-choice procedure where responding was maintained under a fixed-ratio, 5-response schedule of stimulus shock termination. beta-Carboline-3-carboxylate-methyl ester (beta CCM), beta-carboline-3-carboxylate-ethyl ester (beta CCE) and beta-carboline-3-carboxylate-t-butyl ester
W E Hoffman et al.
European journal of pharmacology, 106(3), 585-591 (1984-11-27)
There is a need in clinical practice for an antagonist which can reverse the sedative action of benzodiazepines. Recently, 3-hydroxymethyl-beta-carboline (3-HMC) has been reported to inhibit the sleep inducing effects of flurazepam. The effects of flurazepam (0.5, 5 and 50
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