所有图片(1)
别名:
Diethoxyphosphine oxide, Diethyl acid phosphite, Diethyl hydrogen phosphite, Diethyl phosphonate, Hydrogen diethyl phosphite
线性分子式:
(C2H5O)2P(O)H
CAS号:
分子量:
138.10
Beilstein:
605759
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
检测方案
98%
形式
liquid
折射率
n20/D 1.407 (lit.)
bp
50-51 °C/2 mmHg (lit.)
密度
1.072 g/mL at 25 °C (lit.)
SMILES字符串
[H]P(=O)(OCC)OCC
InChI
1S/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3
InChI key
MJUJXFBTEFXVKU-UHFFFAOYSA-N
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一般描述
Diethyl phosphite is the organophosphorus compound used as a phosphorylating agent in organic synthesis.
应用
Applications of diethyl phosphite (DEP):
- It can undergo condensation with aldehydes or ketones and an amine to form α-aminophosphonates under solvent-free and catalyst-free conditions.
- Reduction of gem-dibromo derivatives using diethyl phosphite in the presence of triethylamine gives monobromocyclopropanes.
- Along with 4-dimethylaminopyridine, it can be used as a ligand for nickel-catalyzed cross-coupling of aryl and heteroaryl bromides, chlorides or sulfonates with arylzinc reagents.
- It can be used for the catalytic asymmetric hydrophosphonylation of enones in the presence of a dinuclear zinc complex to form γ-oxo-phosphonates.
- DEP can undergo Michael addition to α,β-unsaturated malonates to form β-phosphonomalonates in the presence of recyclable nano γ-ferric oxide-pyridine based catalyst.
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Sens. 1B
WGK
WGK 1
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
An efficient Negishi cross-coupling reaction catalyzed by nickel (II) and diethyl phosphite.
Gavryushin A, et al.
Tetrahedron, 62(32), 7521-7533 (2006)
Highly Enantioselective 1,4?Addition of Diethyl Phosphite to Enones Using a Dinuclear Zn Catalyst.
Zhao D, et al.
Chemistry?A European Journal , 15(12), 2738-2741 (2009)
Reduction of gem-dibromides with diethyl phosphite.
Hirao T, et al.
The Journal of Organic Chemistry, 46(18), 3745-3747 (1981)
A simple and green procedure for the synthesis of α-aminophosphonate by a one-pot three-component condensation of carbonyl compound, amine and diethyl phosphite without solvent and catalyst.
Ranu B C and Hajra A
Green Chemistry, 4(6), 551-554 (2002)
Phospha-michael addition of diethyl phosphite to α,β-unsaturated malonates catalyzed by nano γ-Fe2O3-pyridine based catalyst as a new magnetically recyclable heterogeneous organic base.
Sobhani S, et al.
Applied Catalysis A: General, 454, 145-151 (2013)
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