D55008
二氯乙酰氯
98%
别名:
α,α-二氯乙酰氯, 二氯乙酰氯
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关于此项目
线性分子式:
Cl2CHCOCl
化学文摘社编号:
分子量:
147.39
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-199-9
Beilstein/REAXYS Number:
1209426
MDL number:
Assay:
98%
Form:
liquid
InChI key
FBCCMZVIWNDFMO-UHFFFAOYSA-N
InChI
1S/C2HCl3O/c3-1(4)2(5)6/h1H
SMILES string
ClC(Cl)C(Cl)=O
assay
98%
form
liquid
refractive index
n20/D 1.46 (lit.)
bp
107-108 °C (lit.)
density
1.532 g/mL at 25 °C (lit.)
Quality Level
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Carc. 1B - Eye Dam. 1 - Skin Corr. 1A
supp_hazards
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Rolf König et al.
Chemical research in toxicology, 21(3), 572-582 (2008-02-26)
Dichloroacetyl chloride (DCAC) is a reactive metabolite of trichloroethene (TCE). TCE and its metabolites have been implicated in the induction of organ-specific and systemic autoimmunity, in the acceleration of autoimmune responses, and in the development of liver toxicity and hepatocellular
M F Khan et al.
Immunopharmacology and immunotoxicology, 19(2), 265-277 (1997-05-01)
Welders are exposed to dichloroacetyl chloride (DCAC) when trichloroethene (TCE) is used as a degreasing agent. Human exposure to TCE and tetrachloroethane can also lead to formation of DCAC in situ through metabolism. Due to its strong acylating property, it
A R Sellakumar et al.
Journal of the National Cancer Institute, 79(2), 285-289 (1987-08-01)
A series of earlier studies showed that inhalation exposures of rats to three water-reactive electrophilic compounds produced brisk yields of nasal cancer even when the animals were exposed for only 30 days (6 hr/day X 5 day/wk). In addition, carcinogenic
M F Khan et al.
Toxicology and applied pharmacology, 170(2), 88-92 (2001-02-13)
Trichloroethene (TCE) and one of its metabolites dichloroacetyl chloride (DCAC) are known to induce/accelerate autoimmune (AI) response in MRL+/+ mice as evident from anti-nuclear, anti-ssDNA, anti-cardiolipin, and DCAC-specific antibodies in the serum (Khan et al., Toxicol. Appl. Pharmacol. 134, 155-160
Erik N K Cressman et al.
Cardiovascular and interventional radiology (2018-06-07)
Embolotherapies are commonly used for management of primary liver cancer. Explant studies of treated livers, however, reveal an untreated tumor in a high fraction of cases. To improve on this, we propose a new concept referred to as thermoembolization. In
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