推荐产品
质量水平
方案
≥98%
表单
powder
储存温度
−20°C
SMILES字符串
OC(=O)CSSCC(O)=O
InChI
1S/C4H6O4S2/c5-3(6)1-9-10-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
InChI key
DLLMHEDYJQACRM-UHFFFAOYSA-N
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应用
- 二硫代二乙醇酸强化磷酸八钙：研究磷酸八钙的层间距扩增，涉及二硫代二乙醇酸插层分子在层间的强制氧化。代表在材料科学和化学工程领域的新应用(Sugiura et al., 2023)。
- 药物递送系统：研究通过雷公藤内酯增强氧化还原响应型自组装PEG纳米粒子，其中二硫代二乙醇酸发挥了关键作用。代表其可提高抗肿瘤治疗疗效，可用于制药领域(Wang et al., 2018)。
- 合成与药物应用：全面研究经由硫醇的氧化偶联获得的二硫代二乙醇酸衍生物的合成与生物评估。着重在它的药物化学使用，提供药物设计和开发的新方法 (Bakulina et al., 2019)。
- 氧化还原响应型配位聚合物：采用二硫代二乙醇酸开发氧化还原响应型纳米级配位聚合物，用于药物递送和癌症诊疗，推动癌症治疗策略的大步进展(Zhao et al., 2017)。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Huiyun Zhang et al.
International journal of pharmaceutics, 575, 118980-118980 (2020-01-04)
Cardiac glycosides (CGs) have been used to treat cancer for hundreds of years. However, the narrow therapeutic window and system toxicity have hindered their wide clinical applications. Herein, the small molecule prodrug strategy and nanotechnology were integrated into one drug
Hui-Yun Zhang et al.
International journal of pharmaceutics, 555, 270-279 (2018-11-25)
The anti-tumor efficacy of curcumin can be markedly improved by nano-drug self-delivery systems with high drug loading capacity and smart stimulus-triggered drug release in tumor cells. Herein, a type of novel, glutathione (GSH)-responsive, PEGylated prodrug nano-micelles (PPNMs) was prepared by
Shenwu Zhang et al.
Drug delivery, 24(1), 1460-1469 (2017-09-28)
Breast cancer leads to high mortality of women in the world. Docetaxel (DTX) has been widely applied as one of the first-line chemotherapeutic drugs for breast cancer therapy. However, the clinical outcome of DTX is far from satisfaction due to
Huiyun Zhang et al.
Drug development and industrial pharmacy, 46(11), 1800-1808 (2020-09-25)
Curcumin (CUR), a nontoxic natural compound with potent antitumor activity, was limited in clinical application due to its insolubility and exceedingly low bioavailability. In this study, a novel prodrug-nanoparticle (CSSV/TPGS-NPs) self-assembled by co-nanoprecipitation of CUR-s-s-vitamin E conjugate and d-alpha-tocopheryl polyethylene
Huiyun Zhang et al.
Drug delivery, 24(1), 1170-1178 (2017-08-25)
Periplocymarin (PPM), a cardiac glycoside, has a narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity which hinder its wide clinical applications in cancer treatment. Herein, we report novel redox-responsive prodrug-nanoparticles (MPSSV-NPs) self-assembled by co-nanoprecipitation of PPM-vitamin E conjugate
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