D186252
N,N-二甲胺基磺酰氯
99%
别名:
N,N-二甲氨基磺酰氯, 二甲基氨磺酰氯, 二甲氨基磺酰氯
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关于此项目
线性分子式:
(CH3)2NSO2Cl
化学文摘社编号:
分子量:
143.59
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
236-412-4
Beilstein/REAXYS Number:
741979
MDL number:
Assay:
99%
Form:
liquid
InChI key
JFCHSQDLLFJHOA-UHFFFAOYSA-N
InChI
1S/C2H6ClNO2S/c1-4(2)7(3,5)6/h1-2H3
SMILES string
CN(C)S(Cl)(=O)=O
assay
99%
form
liquid
Quality Level
refractive index
n20/D 1.452 (lit.)
bp
114 °C/75 mmHg (lit.)
density
1.337 g/mL at 25 °C (lit.)
Application
N,N -二甲基磺酰氯的用途是：
- 它广泛用于合成一类医药上重要的化合物磺胺类药物。
- 在氨基四氢萘衍生的磺胺化合物的合成中用作抗癌剂 和乙酰胆碱酯酶抑制剂。
- 也可用于羧酸和等摩尔的醇/胺之间的酯化/酰胺化，如香豆素的合成。
signalword
Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Dam. 1 - Skin Corr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
149.0 °F - closed cup
flash_point_c
65 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Novel and efficient method for esterification, amidation between carboxylic acids and equimolar amounts of alcohols, and amines utilizing Me2NSO2Cl and N, N-dimethylamines; its application to the synthesis of coumaperine, a natural chemopreventive dieneamide.
Wakasugi K, et al.
Tetrahedron, 59(28), 5337-5345 (2003)
Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.
Ozgeris B, et al.
Bioorganic & Medicinal Chemistry, 24(10), 2318-2329 (2016)
Catalytic arylation of sulfamoyl chlorides: A practical synthesis of sulfonamides.
Frost CG, et al.
Synlett, 2002(11), 1928-1930 (2002)
Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins.
Ozgeris B, et al.
Archives of Medical Research (2017)
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