质量水平
检测方案
≥98%
形式
powder
mp
171-174 °C (lit.)
储存温度
−20°C
SMILES字符串
[I-].CCCC(=O)SCC[N+](C)(C)C
InChI
1S/C9H20NOS.HI/c1-5-6-9(11)12-8-7-10(2,3)4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChI key
WEQAAFZDJROSBF-UHFFFAOYSA-M
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一般描述
碘化丁酰硫胆碱是丁酰胆碱的一种含硫类似物，用作丁酰胆碱酯酶活性测定试剂。
应用
- 丁酰胆碱酯酶的无标记、超灵敏检测：研究采用基于Mn(II)的电子自旋共振波谱法，超灵敏检测丁酰胆碱酯酶。在有机磷农药存在下，以碘化丁酰硫代胆碱为底物测定酶活性。代表生化试验应用。(Tang et al., 2022)。
- 用于生物传感的新型纳米酶：研发开发了一种Co, N共掺的多孔碳基纳米酶，可作为类氧化酶用于丁酰胆碱酯酶的荧光和比色法生物传感检测。其中，碘化丁酰硫代胆碱为关键底物。代表酶动力学分析相关应用(Sun et al., 2022)。
- 抗阿兹海默症′药物筛选的检测系统：研究构建了铜纳米簇和MnO2纳米片荧光检测平台，用于检测丁酰胆碱酯酶活性（利用碘化丁酰硫代胆碱），继而可用于筛选抗阿兹海默病′药物，并检测胆碱能系统相互作用(Chen et al., 2022)。
- 丁酰胆碱酯酶的双通道检测：研究介绍了融合荧光和氧化酶活性的双功能金属有机框架，开发用于双通道检测丁酰胆碱酯酶（使用碘化丁酰硫代胆碱），改进生化试验方法。(Wang et al., 2022)。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Ganiyu Oboh et al.
Neurotoxicology, 77, 12-19 (2019-12-15)
Many plant foods are rich sources of rutin, a flavonoid with many biological activities and health benefits. Exposure to cadmium has been implicated in neurotoxicity and cognitive dysfunction in animal models. However, there is a dearth of information on the
Cristobal Narvaez et al.
Chemosphere, 135, 75-82 (2015-04-29)
Inhibition of blood esterase activities by organophosphate (OP) pesticides has been used as a sensitive biomarker in birds. Furthermore, compared to mammalian vertebrates, less is known about the role of these enzyme activities in the digestive tracts of non-mammalian vertebrates
Gabriela Fernandes et al.
The journal of adhesive dentistry, 22(3), 265-274 (2020-05-22)
To investigate whether dental adhesives modified with polyacrylic acid copper iodide particles could inhibit esterase activity in vitro and the copper release rate from resin matrices, as well as the correlation between the two variables. Different concentrations of copper iodide
You Zhou et al.
Molecules (Basel, Switzerland), 24(23) (2019-11-24)
As there are increased levels and activity of butyrylcholiesterase (BChE) in the late stage of Alzheimer's disease (AD), development of selective BChE inhibitors is of vital importance. In this study, a workflow combining computational technologies and biological assays were implemented
Gabriele Horn et al.
Archives of toxicology, 89(3), 405-414 (2014-06-11)
Organophosphorus compounds (OP) are bound to human butyrylcholinesterase (BChE) and endogenous or exogenous BChE may act as a stoichiometric scavenger. Adequate amounts of BChE are required to minimize toxic OP effects. Simultaneous administration of BChE and oximes may transfer the
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