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质量水平
方案
99%
表单
liquid
折射率
n20/D 1.541 (lit.)
沸点
134 °C/7 mmHg (lit.)
密度
1.021 g/mL at 25 °C (lit.)
储存温度
2-8°C
SMILES字符串
O=C1CCN(CC1)Cc2ccccc2
InChI
1S/C12H15NO/c14-12-6-8-13(9-7-12)10-11-4-2-1-3-5-11/h1-5H,6-10H2
InChI key
SJZKULRDWHPHGG-UHFFFAOYSA-N
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一般描述
1-苄基-4-哌啶酮在药物化合物的合成中用作通用杂环结构单元。
应用
1-苄基-4-哌啶酮通常用作合成各种药物化合物的结构单元。包括合成以下物质：
- 螺环呋喃并吡啶，作为氟哌啶醇敏感性σ受体配体。
- 多靶向多奈哌齐+炔丙胺+8-羟基喹啉（DPH）杂合体，用于治疗阿尔茨海默病。
- 螺哌啶亚氨基乙内酰脲天冬氨酰蛋白酶抑制剂。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
159.8 °F
闪点(°C)
71 °C
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Maier CA and Wunsch B
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Synthesis and ? receptor affinity of regioisomeric spirocyclic furopyridines.
Miyata K, et al.
European Journal of Medicinal Chemistry, 83(2), 709-716 (2014)
Di-tert-butylsilylene-directed α-selective synthesis of 4-methylumbelliferyl T-antigen.
Imamura A, et al.
Organic Letters, 7(20), 4415-4418 (2005)
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A novel series of 10-benzyl-9(10H)-acridinones and 1-benzyl-4-piperidones were synthesized and tested for their in vitro antitumor activities against CCRF-CEM cells. Assay-based antiproliferative activity study using CCRF-CEM cell lines revealed that the acridone group and the substitution pattern on the benzene
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