A9563
对氨基苯汞乙酸盐
≥90% (titration)
别名:
4-乙酸汞基苯胺, APMA
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线性分子式:
CH3CO2HgC6H4NH2
化学文摘社编号:
分子量:
351.75
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
EC Number:
228-497-1
Beilstein/REAXYS Number:
3664749
MDL number:
InChI key
RXSUFCOOZSGWSW-UHFFFAOYSA-M
InChI
1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1
SMILES string
CC(=O)O[Hg]c1ccc(N)cc1
assay
≥90% (titration)
form
powder
mp
163-165 °C (lit.)
solubility
DMSO: soluble 10 mg/mL, H2O: soluble 5 mM, glacial acetic acid: soluble 50 mg/mL
Quality Level
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Biochem/physiol Actions
基质金属蛋白酶的有机汞活化剂。
Disclaimer
对于美国客户：本品含汞。废弃后切勿放入垃圾桶，须按照地方、州或联邦法律处置。
signalword
Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Equine laminitis: glucose deprivation and MMP activation induce dermo-epidermal separation in vitro.
K R French et al.
Equine veterinary journal, 36(3), 261-266 (2004-05-19)
Acute laminitis is characterised by hoof lamellar dermal-epidermal separation at the basement membrane (BM) zone. Hoof lamellar explants cultured in vitro can also be made to separate at the basement membrane zone and investigating how this occurs may give insight
Jan-Olof Winberg et al.
European journal of biochemistry, 270(19), 3996-4007 (2003-09-27)
In the leukemic macrophage cell-line THP-1, a fraction of the secreted matrix metalloproteinase 9 (MMP-9) is linked to the core protein of chondroitin sulfate proteoglycans (CSPG). Unlike the monomeric and homodimeric forms of MMP-9, the addition of exogenous CaCl2 to
A Bianchi et al.
Osteoarthritis and cartilage, 24(11), 1961-1969 (2016-10-21)
Fibroblast Growth Factor 23 (FGF23) may represent an attractive candidate that could participate to the osteoarthritic (OA)-induced phenotype switch of chondrocytes. To address this hypothesis, we investigated the expression of FGF23, its receptors (FGFRs) and co-receptor (Klotho) in human cartilage
Reihane Ziadlou et al.
Biomolecules, 10(6) (2020-06-25)
In osteoarthritis (OA), inhibition of excessively expressed pro-inflammatory cytokines in the OA joint and increasing the anabolism for cartilage regeneration are necessary. In this ex-vivo study, we used an inflammatory model of human OA chondrocytes microtissues, consisting of treatment with
Fiia P Gäddnäs et al.
Critical care (London, England), 14(2), R49-R49 (2010-04-02)
Matrix metalloproteinases (MMPs) have various roles in inflammatory states. They seem to be able to modulate endothelial barriers and regulate the activity of chemokines and cytokines. The timely development of the levels during severe sepsis and thereafter have not been
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