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质量水平
方案
99%
表单
powder
mp
148-151 °C (lit.)
SMILES字符串
c1cnc2nc[nH]c2c1
InChI
1S/C6H5N3/c1-2-5-6(7-3-1)9-4-8-5/h1-4H,(H,7,8,9)
InChI key
GAMYYCRTACQSBR-UHFFFAOYSA-N
Andrea Cappelli et al.
Journal of medicinal chemistry, 49(22), 6451-6464 (2006-10-27)
The 4-phenylquinoline fragment of novel AT(1) receptor antagonists 4 based on imidazo[4,5-b]pyridine moiety was replaced by 4-phenylisoquinolinone (compounds 5) or 1-phenylindene (compounds 6) scaffolds to investigate the structure-activity relationships. Binding studies showed that most of the synthesized compounds display high
Ping Lan et al.
European journal of medicinal chemistry, 46(1), 77-94 (2010-11-26)
3D-QSAR and docking studies were performed on sixty imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors. The CoMFA and CoMSIA models using forthy-eight molecules in the training set, gave r(cv)(2) values of 0.774 and 0.800, r(2) values of 0.975 and 0.977
Dorte Renneberg et al.
Journal of the American Chemical Society, 125(19), 5707-5716 (2003-05-08)
The DNA binding properties of fused heterocycles imidazo[4,5-b]pyridine (Ip) and hydroxybenzimidazole (Hz) paired with pyrrole (Py) in eight-ring hairpin polyamides are reported. The recognition profile of Ip/Py and Hz/Py pairs were compared to the five-membered ring pairs Im/Py and Hp/Py
Vassilios Bavetsias et al.
Bioorganic & medicinal chemistry letters, 17(23), 6567-6571 (2007-10-16)
A hit generation and exploration approach led to the discovery of 31 (2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide), a potent, novel inhibitor of Aurora-A, Aurora-B and Aurora-C kinases with IC(50) values of 0.042, 0.198 and 0.227microM, respectively. Compound 31 inhibits cell proliferation and has good
S Piras et al.
Farmaco (Societa chimica italiana : 1989), 48(9), 1249-1259 (1993-09-01)
Twenty compounds possessing benzimidazole, imidazo[4,5-b]pyridine and quinoxaline structure bearing either a substituted arylmethylmercapto- or an arylmethylsulfinyl group in position 2 were prepared in order to evaluate an antiulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole at
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