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检测方案
97%
形式
liquid
折射率
n20/D 1.475 (lit.)
bp
146 °C/730 mmHg (lit.)
密度
0.928 g/mL at 25 °C (lit.)
SMILES字符串
NN1CCCCC1
InChI
1S/C5H12N2/c6-7-4-2-1-3-5-7/h1-6H2
InChI key
LWMPFIOTEAXAGV-UHFFFAOYSA-N
应用
1-氨基哌啶可作为反应物与甲酸乙酯反应制得N-1-哌啶基甲酰胺。也与氢化铝、氢化镓反应生成相应的酰肼。在制药工业中，氨基哌啶被用作合成各种生物活性分子的构件。
用于合成以下物质的反应物：
- CB1大麻素受体配体†
- 腙类†
- 四氢萘衍生物对LPS激活RAW 264.7巨噬细胞增殖和一氧化氮生成的影响
- 磷（V）肼
其他说明
剩余哌啶
警示用语：
Warning
危险分类
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Aluminum and gallium hydrazides derived from N-aminopyrrole and N-aminopiperidine
Uhl Werner, et al.
Zeitschrift fur Naturforschung B, 61(7), 854-861 (2006)
Thomas Lübbers et al.
Bioorganic & medicinal chemistry letters, 17(11), 2966-2970 (2007-04-10)
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR
Fernando C Baltanás et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188445-188445 (2020-10-10)
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are responsible for different intramolecular
G Lunn et al.
Environmental and molecular mutagenesis, 17(1), 59-62 (1991-01-01)
When 1,1-dimethylhydrazine and N-aminopiperidine were deliberately exposed to air substantial amounts of the corresponding carcinogenic nitrosamines were formed. Unoxidized samples of 1,1-dimethylhydrazine were not mutagenic while oxidized samples (which contained much higher levels of nitrosamines) were mutagenic. Both unoxidized and
N-Isocyanodialkylamines generated in situ for the Joullie-Ugi reaction with indolenines
Golubev P and Krasavin M
Tetrahedron Letters, 59(39), 3532-3536 (2018)
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