A2898
4-氨基联苯
≥98%
别名:
4-氨基联苯, 4-联苯胺, 4-苯基苯胺, NSC 7660, 对氨基苯胺, 联苯-4-基胺, 联苯基胺
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线性分子式:
C6H5C6H4NH2
化学文摘社编号:
分子量:
169.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-177-1
Beilstein/REAXYS Number:
386533
MDL number:
产品名称
4-氨基联苯, ≥98%
InChI
1S/C12H11N/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,13H2
InChI key
DMVOXQPQNTYEKQ-UHFFFAOYSA-N
SMILES string
Nc1ccc(cc1)-c2ccccc2
assay
≥98%
form
solid
autoignition temp.
842 °F
bp
191 °C/15 mmHg (lit.)
mp
52-54 °C (lit.)
Quality Level
Gene Information
human ... UGT1A4(54657)
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Application
- 诱导人膀胱癌细胞和小鼠膀胱组织DNA损伤（致癌物）
- 用于富集、消耗和一步纯化水蛭蛋白的合成胺配体
Biochem/physiol Actions
实验动物模型的肝肿瘤引发剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
K L Dooley et al.
Cancer letters, 62(3), 205-209 (1992-03-15)
The tumorigenic activities of four representative heterocyclic amine food pyrolysates, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were assessed in the neonatal male B6C3F1 mouse and were compared with that of the potent human carcinogen, 4-amino-biphenyl (4-ABP). These
Dexian Dong et al.
Journal of molecular recognition : JMR, 21(3), 163-168 (2008-04-29)
Although the concept of affinity purification using synthetic ligands had been utilized for many years, there are few articles related to this research area, and they focus only on the affinity purification of specific protein by a defined library of
Moinuddin et al.
Environmental toxicology, 29(5), 568-576 (2012-05-23)
4-Aminobiphenyl (4-ABP), an aromatic amine is a major environmental carcinogen found mainly in cigarette smoke. It has been vastly implicated in mutagenesis and cancer development. In this study, commercially available human placental DNA was exposed to 4-ABP (1.3 mM) in
Samuel M Cohen et al.
Critical reviews in toxicology, 36(10), 803-819 (2006-11-23)
The IPCS Human Relevance Framework was evaluated for a DNA-reactive (genotoxic) carcinogen, 4-aminobiphenyl, based on a wealth of data in animals and humans. The mode of action involves metabolic activation by N-hydroxylation, followed by N-esterification leading to the formation of
Kristen L Randall et al.
Journal of chromatography. A, 1217(25), 4135-4143 (2009-11-26)
Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the bladder urothelium, leads to DNA adduct formation and cancer development [1]. Two major analytical challenges in DNA adduct analysis of human samples have been limited sample availability
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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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