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蒸汽压
0.3 psi ( 20 °C)
质量水平
方案
99%
表单
liquid
包含
H3PO4 as stabilizer (Europe)
sulfuric acid as stabilizer (US)
expl. lim.
11 %
折射率
n20/D 1.399 (lit.)
沸点
82 °C/23 mmHg (lit.)
mp
−19 °C (lit.)
密度
0.932 g/mL at 25 °C (lit.)
SMILES字符串
CC(C)(O)C#N
InChI
1S/C4H7NO/c1-4(2,6)3-5/h6H,1-2H3
InChI key
MWFMGBPGAXYFAR-UHFFFAOYSA-N
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一般描述
丙酮氰醇可用作Mitsunobu 反应中的氢氰酸源。也是甲基丙烯酰胺合成的中间体。
应用
丙酮氰醇可用作以下反应的氰化物来源：
- 芳基卤化物、 醛类 和酒精的氰化反应。
- 立体特异性环氧化物开环反应。
- α-酰胺基砜的Strecker 反应，以合成 α-氨基腈。
警示用语：
Danger
危险分类
Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
167.0 °F - closed cup
闪点(°C)
75 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
Z I Zholdakova et al.
Gigiena i sanitariia, (8)(8), 16-18 (1994-09-01)
The study of acetone cyanohydrin (ACH) showed that it is an unstable substance. Its stability in water depends on pH of water and less so on its initial concentration; water temperature and biota are insignificant. Acetone and cyanid-ion, forming from
Regiospecific opening of 1, 2-expoxides with acetone cyanohydrin under mildly basic conditions.
Mitchell D and Koenig TM
Tetrahedron Letters, 33(23), 3281-3284 (1992)
Rondon Tosta Ramalho et al.
Acta cirurgica brasileira, 25(1), 111-116 (2010-02-04)
To evaluate the antitumor effect of acetone cyanohydrin in Ehrlich ascites tumor cells in vitro. The Ehrlich ascites tumor cells and lymphocytes were incubated with different concentrations of acetone cyanohydrin (0, 0.5, 1.0, 2.0, 10.0, 20.0 and 30.0 microg x
H Lauble et al.
Protein science : a publication of the Protein Society, 10(5), 1015-1022 (2001-04-24)
The structure and function of hydroxynitrile lyase from Manihot esculenta (MeHNL) have been analyzed by X-ray crystallography and site-directed mutagenesis. The crystal structure of the MeHNL-S80A mutant enzyme has been refined to an R-factor of 18.0% against diffraction data to
Zr (OBut)4 As an effective promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes: development of new asymmetric cyanohydrin synthesis.
Ooi T, et al.
Tetrahedron, 57(5), 867-873 (2001)
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