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Merck
CN

940674

Sigma-Aldrich

DBCO-NHCO-PEG4-amine TFA

new

≥95%

别名:

15-Amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-4,7,10,13-tetraoxapentadecanamide, 4,7,10,13-Tetraoxapentadecanamide, 15-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl], ADIBO-PEG4-amine TFA

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About This Item

经验公式(希尔记法):
C29H37N3O6 · xC2HF3O2
分子量:
523.62 (free base basis)
MDL编号:

质量水平

方案

≥95%

表单

solid

颜色

colorless to yellow-brown

储存温度

−20°C

SMILES字符串

O=C(NCCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1)CCOCCOCCOCCOCCN

InChI

1S/C29H37N3O6.C2HF3O/c30-13-16-36-18-20-38-22-21-37-19-17-35-15-12-28(33)31-14-11-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32;3-2(4,5)1-6/h1-8H,11-23,30H2,(H,31,33);1H

InChI key

MRRSYYMIRSTYMO-UHFFFAOYSA-N

应用

DBCO-PEG4-Amine TFA is a heterobifunctional building block with two reactive terminals. The Dibenzocyclooctyne (DBCO) terminus is useful for copper-free click chemistry. DBCO compounds react with azides without need of Cu(I) catalyst due to the strained nature of alkyne resulting in formation of fast and stable triazole linkage. The amine terminus is useful for reaction with carboxylic acid containing linkers in presence in actiavtors such as EDC or HATU.

特点和优势

The PEG4 linker is suited for improving solubility of resulting conjugates and provides sufficient length to minimize interactions between macromolecules of interest.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Click chemistry for the preparation of advanced macromolecular architectures
Akeroyd N, et al.
European Polymer Journal, 47, 1207-1231 (2010)
Pamela V Chang et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(5), 1821-1826 (2010-01-19)
Chemical reactions that enable selective biomolecule labeling in living organisms offer a means to probe biological processes in vivo. Very few reactions possess the requisite bioorthogonality, and, among these, only the Staudinger ligation between azides and triarylphosphines has been employed
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Vsevolod V Rostovtsev et al.
Angewandte Chemie (International ed. in English), 41(14), 2596-2599 (2002-08-31)

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