NanoFabTx^™ NanoFlash CIJ device

The NanoFabTx^™ NanoFlash CIJ device is a cutting-edge solution designed for precise and efficient synthesis of nanoparticles. This nanoparticle device uses a confined impinging jet (CIJ) mixer for the flash nanoprecipitation of nanoparticles. Flash nanoprecipitation is a simple and scalable technique whereby a drug solution and non-solvent rapidly mix to create high supersaturation conditions, and sequential precipitation and encapsulation of drugs or other molecules in various delivery vehicles such as polymers and lipids. This state-of-the-art technology offers exceptional control over particle size and encapsulation efficiency, enabling researchers to explore new frontiers in drug delivery, nanoformulation, nanoscience, and other nanoparticle-based applications.

The NanoFabTx^™ NanoFlash CIJ device empowers researchers in academia, pharma, biotech, and industry to accelerate their nanoparticle synthesis projects with superior control and efficiency. From drug delivery systems and imaging agents to catalysis and nanocomposite materials, the possibilities for innovation are extensive. Common applications include:

• Lipid nanoparticle (LNP) formulations for mRNA vaccines, nucleic acids, and other gene therapy modalities
• Polymeric drug delivery nanoparticles for hydrophobic and hydrophilic small molecules
• Assembly and loading of solid-core theranostic nanoparticles for cancer imaging

The NanoFabTx^™ NanoFlash CIJ device for nanoparticle synthesis is ready-to-use and includes all of the necessary tubing and accessories to begin your nanoparticle research journey. Additional features and benefits include:

• Rapid and controlled nanoparticle synthesis - The NanoFabTx^™ NanoFlash CIJ device design ensures rapid and efficient precipitation and subsequent nanoparticle formulation. The result is precise control over particle size distribution, drug encapsulation, and other desired characteristics.
• Versatile nanoparticle synthesis - This device enables the synthesis of a wide range of nanoparticles including polymer nanoparticles, liposomes, lipid nanoparticles, micelles, and hybrid nanoparticles. Its versatility allows researchers to tailor the composition and properties of nanoparticles to meet specific application requirements. We have developed NanoFabTx^™ polymer kits and lipid mixes specifically designed to be used with the NanoFabTx^™ Nanoflash CIJ device which include detailed step by step protocols for fine-tuned, drug encapsulated nanoparticle synthesis.
• Fine-tuned particle size control - The flash nanoprecipitation technique employed by the NanoFabTx^™ NanoFlash CIJ device offers exceptional control over particle size, ranging from
• Easy operation and flexibility - The NanoFabTx^™ NanoFlash CIJ device is user-friendly and ready to use right out of the box. The housing allows for ease of use and cleaning, while also acting as a storage unit for additional tubing and accessories. The device is designed to be used with a with a pump system, such as a syringe pump or pressurized pump, or via hand depression of syringes using the hand depression plate. Protocols for both methods are included under the "more documents" section of this page.
• Scalable and reproducible - The NanoFabTx^™ is designed for scalability, allowing researchers to seamlessly transition from lab-scale to larger production volumes without compromising performance or reproducibility. The robust and reliable design ensure consistent results, delivery batch-to-batch reliability and eliminating variability.

Additional information including a step by step protocol can be found under the more documents section of this page. Click here https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/flash-nanoprecipitation to learn more about flash nanoprecipitation.

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC