937177
Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide
PEG average Mn 2000, PLLA average Mn 10000
别名:
Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL10k, mPEGNH2-PLL
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所有图片(1)
About This Item
线性分子式:
C3H9NO(OC2H4)x-(C6H13N2OBr)n
UNSPSC代码:
12162002
NACRES:
NA.21
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一般描述
Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications to improve therapeutic efficacy. The cationic PLL block can bind to DNA or RNA, as well as other therapeutic agents, while the amine-functionalized PEG block inhibits protein adsorption and can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.
应用
- Non-viral gene delivery applications
- Targeted drug delivery applications
- Protein coatings and tissue culture
特点和优势
- Self-assemble capability to form micelles and polymersomes
- Amine functional group at the side chain enables further rapid functionalization
- Cationic poly(L-lysine) has excellent DNA and RNA condensation property
- Biodegradable, biocompatible and water soluble
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Poly (??amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)
Iqbal S, et al.
European Polymer Journal, 141, 110097-110097 (2020)
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Karlsson J, et al.
Expert Opinion on Drug Delivery, 17, 1395-1410 (2020)
Qi Y Wang et al.
Journal of materials chemistry. B, 7(7), 1076-1086 (2019-02-21)
Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL)
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