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描述
Degree of functionalization: 10-30% methacrylation
质量水平
表单
powder or chunks (or fibers)
颜色
white to off-white
储存温度
2-8°C
一般描述
Heparin methacrylate (HepMa) is a functionalized natural polymer that can be used in 3D bioprinting and tissue engineering applications.
Heparin is a naturally occurring linear biopolymer and highly sulfated glycosaminoglycan (GAG). Research has demonstrated that heparin can modulate binding extracellular matrix proteins and sequester growth factors and cytokines, making them useful in 3D applications. The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water.
Heparin is a naturally occurring linear biopolymer and highly sulfated glycosaminoglycan (GAG). Research has demonstrated that heparin can modulate binding extracellular matrix proteins and sequester growth factors and cytokines, making them useful in 3D applications. The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water.
应用
Heparin based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.
特点和优势
- Batch control offers reproducible models for preclinical toxicology testing and drug screening
- Extended shelf-life & stability
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Anastasia Nilasaroya et al.
Biomaterials, 29(35), 4658-4664 (2008-09-19)
Synthetic scaffolds show great promise for use in tissue engineering due to their ability to mimic some aspects of the extracellular matrix, however, their use has been hindered by the lack of inherent recognition sites that are required for protein
Hangjun Ding et al.
ACS nano, 8(5), 4348-4357 (2014-04-18)
The emergence of flexible and stretchable electronic components expands the range of applications of electronic devices. Flexible devices are ideally suited for electronic biointerfaces because of mechanically permissive structures that conform to curvilinear structures found in native tissue. Most electronic
Danielle S W Benoit et al.
Biomaterials, 28(1), 66-77 (2006-09-12)
Poly(ethylene glycol) (PEG) hydrogels functionalized with heparin were utilized as a three-dimensional culture system for human mesenchymal stem cells (hMSCs). Heparin-functionalized hydrogels supported hMSC viability, as quantified through live/dead imaging, and induced osteogenic differentiation, as measured by increased alkaline phosphatase
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