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Merck
CN

934569

Sigma-Aldrich

NanoFabTx Photoactivatable Lipid

redAzoPC

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About This Item

经验公式(希尔记法):
C46H72Cl4N3O8P
分子量:
967.86
UNSPSC代码:
12161503
NACRES:
NA.21

质量水平

检测方案

≥90%

形式

solid

颜色

orange to dark red

储存温度

−20°C

SMILES字符串

[O-]P(OCC[N+](C)(C)C)(OC[C@H](OC(CCCC1=CC(Cl)=C(C(Cl)=C1)/N=N/C2=C(C=C(C=C2Cl)CCCC)Cl)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

一般描述

The NanoFabTx Photoactivatable Lipid, redAzoPC is a red-light photoswitchable lipid for controlled and targeted drug delivery. The tetra-ortho-chloro-azobenzene of redAzoPC can be isomerized from the cis to the trans conformation at 660 nm light. LNPs prepared using the NanoFabTx Photoactivatable Lipid, redAzoPC result in controlled drug release following deep red light irradiation.

应用

Lipid nanoparticle and liposome drug delivery systems

特点和优势

  • Similar drug loading, encapsulation efficiency, size, and polydispersity to non-photoswitchable lipids
  • Light-induced drug delivery
  • Targeted and controlled release
  • Overcomes limitations associated to UV-switchable lipids

法律信息

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Nisha Chander et al.
Small (Weinheim an der Bergstrasse, Germany), 17(21), e2008198-e2008198 (2021-04-22)
Encapsulation of small molecule drugs in long-circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site
Johannes Morstein et al.
Chembiochem : a European journal of chemical biology, 22(1), 73-83 (2020-08-14)
Photoswitchable lipids are emerging tools for the precise manipulation and study of lipid function. They can modulate many aspects of membrane biophysics, including permeability, fluidity, lipid mobility and domain formation. They are also very useful in lipid physiology and enable
Tufan K Mukhopadhyay et al.
Current opinion in pharmacology, 63, 102202-102202 (2022-03-13)
Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their

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