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Merck
CN

934356

Sigma-Aldrich

Val-cit-PAB-OH

≥95%

别名:

L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethylphenyl]-L-ornithinamide, L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide

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About This Item

经验公式(希尔记法):
C18H29N5O4
分子量:
379.45
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.21

质量水平

方案

≥95%

表单

powder

储存温度

2-8°C

SMILES字符串

N([C@@H](CCCNC(=O)N)C(=O)Nc1ccc(cc1)CO)C(=O)[C@@H](N)C(C)C

InChI

1S/C18H29N5O4/c1-11(2)15(19)17(26)23-14(4-3-9-21-18(20)27)16(25)22-13-7-5-12(10-24)6-8-13/h5-8,11,14-15,24H,3-4,9-10,19H2,1-2H3,(H,22,25)(H,23,26)(H3,20,21,27)/t14-,15-/m0/s1

InChI key

VEGGTWZUZGZKHY-GJZGRUSLSA-N

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应用

This is a cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).

Cathepsin cleaveable linkers

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

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分析证书(COA)

Lot/Batch Number

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Qinhuai Lai et al.
European journal of medicinal chemistry, 199, 112364-112364 (2020-05-14)
Cryptophycin-52 (CR52), a tubulin inhibitor, exhibits promising antitumor activity in vitro (picomolar level) and in mouse xenograft models. However, the narrow therapeutic window in clinical trials limits its further development. Antibody-drug conjugate (ADC), formed by coupling cytotoxic compound (payload) to an
Zixuan Ye et al.
International journal of nanomedicine, 16, 2443-2459 (2021-04-06)
Specific modifications to carriers to achieve targeted delivery of chemotherapeutics into malignant tissues are a critical point for efficient diagnosis and therapy. In this case, bovine serum albumin (BSA) was conjugated with cetuximab-valine-citrulline (vc)-doxorubicin (DOX) to target epidermal growth factor

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