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质量水平
方案
≥95%
表单
powder
储存温度
2-8°C
SMILES字符串
ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
InChI
1S/C19H21Cl2N3O6/c1-10(2)7-14(19(29)30-24-16(26)5-6-17(24)27)23-15(25)9-22-18(28)12-8-11(20)3-4-13(12)21/h3-4,8,10,14H,5-7,9H2,1-2H3,(H,22,28)(H,23,25)/t14-/m0/s1
InChI key
KCUJPSDSTWVHLQ-AWEZNQCLSA-N
应用
CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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