form
solid (Chunks)
color
white to off-white
application(s)
3D bioprinting
storage temp.
2-8°C
Quality Level
Application
Hyaluronic acid (HA) is a ubiquitous extracellular matrix component, which makes it attractive for use in medical applications for it′s biocompatibility and low immunogenicity. HA-based polymers are used to make hydrogels for a wide variety of applications from tissue engineering and regeneration to drug delivery and bioinks for 3D bioprinting. To make hydrogels, HA has to be derivatized with groups that can cross-link to to other functionalized polymers.
General description
Adipic acid dihydrazide is commonly used as a functional group to allow for HA cross-linking to polymers containing aldehyde groups or that are aldehyde-functionalized, like HA-aldehyde or PEG-aldehyde. These biomaterials are attractive for their tunable properties and low cytotoxicity.
Degree of functionalization (50-80%)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering
Chen, et al.
Carbohydrate Polymers, 166, 31-44 (2017)
Xinqiao Jia et al.
Biomacromolecules, 7(12), 3336-3344 (2006-12-13)
Vocal fold scarring disrupts the viscoelastic properties of the lamina propria that are critical for normal phonation. There is a clinical need for the development of advanced biomaterials that approximate the mechanical properties of the lamina propria for in vivo
Yuguo Lei et al.
Biomaterials, 32(1), 39-47 (2010-10-12)
Synthetic hydrogel scaffolds that can be used as culture systems that mimic the natural stem cell niche are of increased importance for stem cell biology and regenerative medicine. These artificial niches can be utilized to control the stem cell fate
商品
Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.
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