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Merck
CN

928380

Sigma-Aldrich

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid

≥95%

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About This Item

经验公式(希尔记法):
C18H29N5O5
分子量:
395.45
UNSPSC代码:
12352106
NACRES:
NA.22

质量水平

方案

≥95%

表单

powder

反应适用性

reagent type: linker

官能团

Boc
amine
carboxylic acid

储存温度

2-8°C

应用

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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