927473
CA-alkyne
≥95%
别名:
2-Chloro-N-(hex-5-yn-1-yl)acetamide
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关于此项目
经验公式（希尔记法）:
C8H12ClNO
化学文摘社编号:
分子量:
173.64
MDL number:
UNSPSC Code:
12352101
NACRES:
NA.21
产品名称
CA-alkyne, ≥95%
InChI key
YQDXXLTYDIDZDT-UHFFFAOYSA-N
InChI
1S/C8H12ClNO/c1-2-3-4-5-6-10-8(11)7-9/h1H,3-7H2,(H,10,11)
SMILES string
ClCC(=O)NCCCCC#C
assay
≥95%
form
semisolid
storage temp.
−20°C
Quality Level
Application
CA-alkyne is a probe that can be used for labeling cysteines through alkylation. For the corresponding negative control, see CA-nitrile. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications. The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis. Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Profiling the proteome-wide selectivity of diverse electrophiles
Zanon, et al
ChemRxiv : the preprint server for chemistry (2021)
Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)
Eranthie Weerapana et al.
Nature, 468(7325), 790-795 (2010-11-19)
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here we
Keriann M Backus et al.
Nature, 534(7608), 570-574 (2016-06-17)
Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered 'undruggable'. Fragment-based ligand discovery can identify small-molecule probes for proteins
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