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Merck
CN
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文件

安全信息

927449

Sigma-Aldrich

SDASO-L crosslinker

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别名:
2,5-Dioxopyrrolidin-1-yl 3-((2-(3-(3-methyl-3H-diazirin-3-yl)propanamido)ethyl)sulfinyl) propanoate, Succinimidyl diazirine sulfoxide
经验公式（希尔记法）:
C14H20N4O6S
分子量:
372.40

形式

chunks

质量水平

100

储存温度

−20°C

SMILES字符串

C1C(N(C(C1)=O)OC(CC[S](CCN(C(CCC2([C])N=N2)=O)[H])=O)=O)=O

应用

SDASO-L (succinimidyl diazirine sulfoxide, long version) is mass-spectrometry cleavable heterobifunctional cross-linker, which can be used in the analysis of protein structure, or protein-protein interactions. SDASO-L is photoactivated, allowing for the first time photocross-linking of proteins, and rapid, accurate analysis by MS.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

其他说明

Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers

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WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Craig Gutierrez et al.
Molecular & cellular proteomics : MCP, 20, 100084-100084 (2021-04-30)
Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein-protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions nontargetable by specific chemistries remain difficult. Photochemistry has shown great

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