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质量水平
储存温度
−20°C
1 of 4
此商品 | SML2819 | SML0651 | P0036 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: >10 mg/mL |
| color white to light brown | color white to beige | color white to beige | color off-white |
一般描述
NanoFabTx™-DC-Chol Lipid Mix; for synthesis of cationic (DC-cholesterol) liposomes is a ready-to-use nanoformulation blend for the synthesis of liposomes for drug delivery. The NanoFabTx™-DC-Chol Lipid Mix includes optimized protocols with step-by-step instructions for synthesizing cationic DC-cholesterol liposomes for drug delivery applications. The modification of the liposomes with the cationic lipid, DC-cholesterol, have numerous advantages including high gene transfection efficiency. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.
应用
About NanoFabTx™
NanoFabTx™ lipid mixes and formulation kits enable users to encapsulate a wide variety of therapuetic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ reagent kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
NanoFabTx™ lipid mixes and formulation kits enable users to encapsulate a wide variety of therapuetic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ reagent kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
特点和优势
- A ready-to-use nanoformulation blend for the synthesis of cationic DC-cholesterol liposomes
- Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
- Flexible synthesis tools to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- DC-Cholesterol allows for high transfection efficiency and targeted drug delivery
- A lipid film hydration and extrusion protocol.
- A microfluidics protocol using commercial platforms or syringe pumps.
法律信息
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy
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Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG-PE) into large unilamellar liposomes composed of egg phosphatidylcholine:cholesterol (1:1) does not significantly increase the content leakage when the liposomes are exposed to 90% human serum at 37 degrees C, yet the liposomes show
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